M74R (p.Met74Arg) variant of COMP (P49747)
M74R (p.Met74Arg) in COMP (P49747) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.49 / 1. The record also includes population frequency data and structural context.
M74R (p.Met74Arg) variant details
- p.Met74Arg
- gnomAD rs2055201399
- Missense
- Variant Prioritization Score for Impact Estimate 0.486
- REVEL 0.37
- ESM-1b 0.95
- AlphaMissense 0.22
- CADD 20.80
- PolyPhen-2 0.00
- SIFT 0.51
- Most common in the Finnish in Finland (FIN) population (allele frequency 9.5e-05)
- Structural context available