W15L (p.Trp15Leu) variant of CLU (Clusterin)
W15L (p.Trp15Leu) in CLU (Clusterin) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.33 / 1. The record also includes population frequency data and structural context.
W15L (p.Trp15Leu) variant details
- p.Trp15Leu
- ESP rs150750334
- ExAC rs150750334
- TOPMed rs150750334
- gnomAD rs150750334
- Missense
- Variant Prioritization Score for Impact Estimate 0.326
- REVEL 0.16
- CADD 18.60
- PolyPhen-2 0.08
- SIFT 0.23
- Most common in the African/African-American population (allele frequency 4.8e-05)
- Structural context available