V20L (p.Val20Leu) variant of CLU (Clusterin)
V20L (p.Val20Leu) in CLU (Clusterin) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.34 / 1. The record also includes population frequency data and structural context.
V20L (p.Val20Leu) variant details
- p.Val20Leu
- TOPMed rs1269799789
- gnomAD rs1269799789
- Missense
- Variant Prioritization Score for Impact Estimate 0.335
- REVEL 0.17
- CADD 23.30
- PolyPhen-2 0.96
- SIFT 0.12
- Most common in the Latino/Admixed American population (allele frequency 2.2e-05)
- Structural context available