T25R (p.Thr25Arg) variant of CLU (Clusterin)
T25R (p.Thr25Arg) in CLU (Clusterin) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.05 / 1. The record also includes population frequency data and structural context.
T25R (p.Thr25Arg) variant details
- p.Thr25Arg
- 1000Genomes rs543157739
- ExAC rs543157739
- TOPMed rs543157739
- gnomAD rs543157739
- Missense
- Variant Prioritization Score for Impact Estimate 0.0503
- REVEL 0.03
- CADD 1.73
- PolyPhen-2 0.02
- SIFT 0.53
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available