T105I (p.Thr105Ile) variant of CLU (Clusterin)
T105I (p.Thr105Ile) in CLU (Clusterin) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.38 / 1. The record also includes population frequency data and structural context.
T105I (p.Thr105Ile) variant details
- p.Thr105Ile
- ExAC rs754785720
- TOPMed rs754785720
- gnomAD rs754785720
- Missense
- Variant Prioritization Score for Impact Estimate 0.378
- REVEL 0.26
- CADD 24.50
- PolyPhen-2 0.95
- SIFT 0.00
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available