S161Y (p.Ser161Tyr) variant of CLU (Clusterin)
S161Y (p.Ser161Tyr) in CLU (Clusterin) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.36 / 1. The record also includes population frequency data and structural context.
S161Y (p.Ser161Tyr) variant details
- p.Ser161Tyr
- ExAC rs775465384
- gnomAD rs775465384
- Missense
- Variant Prioritization Score for Impact Estimate 0.357
- REVEL 0.14
- CADD 25.10
- PolyPhen-2 0.69
- SIFT 0.00
- Most common in the Ashkenazi Jewish population (allele frequency 3.8e-05)
- Structural context available