R67S (p.Arg67Ser) variant of CLU (Clusterin)
R67S (p.Arg67Ser) in CLU (Clusterin) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.40 / 1. The record also includes population frequency data and structural context.
R67S (p.Arg67Ser) variant details
- p.Arg67Ser
- TOPMed rs11555224
- Missense
- Variant Prioritization Score for Impact Estimate 0.399
- REVEL 0.29
- CADD 24.70
- PolyPhen-2 0.92
- SIFT 0.02
- Most common in the Middle Eastern population (allele frequency 0.00017)
- Structural context available