R67C (p.Arg67Cys) variant of CLU (Clusterin)
R67C (p.Arg67Cys) in CLU (Clusterin) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.37 / 1. The record also includes population frequency data and structural context.
R67C (p.Arg67Cys) variant details
- p.Arg67Cys
- cosmic curated COSV57067
- TOPMed rs11555224
- Missense
- Variant Prioritization Score for Impact Estimate 0.373
- REVEL 0.26
- CADD 24.00
- PolyPhen-2 0.37
- SIFT 0.00
- Most common in the REMAINING population (allele frequency 1.7e-05)
- Structural context available