R158L (p.Arg158Leu) variant of CLU (Clusterin)
R158L (p.Arg158Leu) in CLU (Clusterin) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.43 / 1. The record also includes population frequency data and structural context.
R158L (p.Arg158Leu) variant details
- p.Arg158Leu
- ExAC rs772557487
- TOPMed rs772557487
- gnomAD rs772557487
- Missense
- Variant Prioritization Score for Impact Estimate 0.432
- REVEL 0.19
- CADD 24.80
- PolyPhen-2 0.49
- SIFT 0.00
- Population evidence available
- Structural context available