R138H (p.Arg138His) variant of CLU (Clusterin)
R138H (p.Arg138His) in CLU (Clusterin) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.13 / 1. The record also includes population frequency data and structural context.
R138H (p.Arg138His) variant details
- p.Arg138His
- rs756208273
- NCI-TCGA Cosmic COSV1003
- cosmic curated COSV10032
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.134
- REVEL 0.11
- CADD 13.70
- PolyPhen-2 0.02
- SIFT 0.29
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Latino/Admixed American population (allele frequency 0.00018)
- Structural context available