L74V (p.Leu74Val) variant of CLU (Clusterin)
L74V (p.Leu74Val) in CLU (Clusterin) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.22 / 1. The record also includes population frequency data and structural context.
L74V (p.Leu74Val) variant details
- p.Leu74Val
- TOPMed rs956433124
- gnomAD rs956433124
- Missense
- Variant Prioritization Score for Impact Estimate 0.224
- REVEL 0.25
- CADD 15.60
- PolyPhen-2 0.97
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 2.7e-06)
- Structural context available