L31I (p.Leu31Ile) variant of CLU (Clusterin)
L31I (p.Leu31Ile) in CLU (Clusterin) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.51 / 1. The record also includes population frequency data and structural context.
L31I (p.Leu31Ile) variant details
- p.Leu31Ile
- TOPMed rs1800903305
- Missense
- Variant Prioritization Score for Impact Estimate 0.508
- REVEL 0.33
- CADD 24.20
- PolyPhen-2 1.00
- SIFT 0.01
- Most common in the Latino/Admixed American population (allele frequency 2.2e-05)
- Structural context available