L21V (p.Leu21Val) variant of CLU (Clusterin)
L21V (p.Leu21Val) in CLU (Clusterin) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.29 / 1. The record also includes population frequency data and structural context.
L21V (p.Leu21Val) variant details
- p.Leu21Val
- Ensembl rs754279494
- Missense
- Variant Prioritization Score for Impact Estimate 0.292
- REVEL 0.16
- CADD 24.10
- PolyPhen-2 0.97
- SIFT 0.04
- Most common in the Finnish in Finland (FIN) population (allele frequency 1.9e-05)
- Structural context available