E87D (p.Glu87Asp) variant of CLU (Clusterin)
E87D (p.Glu87Asp) in CLU (Clusterin) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.07 / 1. The record also includes population frequency data and structural context.
E87D (p.Glu87Asp) variant details
- p.Glu87Asp
- TOPMed rs1800825325
- NCI-TCGA Cosmic COSV5706
- cosmic curated COSV57065
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.0713
- REVEL 0.06
- CADD 2.90
- PolyPhen-2 0.01
- SIFT 0.62
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the East Asian population (allele frequency 2.5e-05)
- Structural context available