E33Q (p.Glu33Gln) variant of CLU (Clusterin)
E33Q (p.Glu33Gln) in CLU (Clusterin) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.34 / 1. The record also includes population frequency data and structural context.
E33Q (p.Glu33Gln) variant details
- p.Glu33Gln
- gnomAD rs1235465645
- Missense
- Variant Prioritization Score for Impact Estimate 0.337
- REVEL 0.15
- CADD 23.60
- PolyPhen-2 0.95
- SIFT 0.50
- Most common in the Latino/Admixed American population (allele frequency 4.5e-05)
- Structural context available