E142K (p.Glu142Lys) variant of CLU (Clusterin)
E142K (p.Glu142Lys) in CLU (Clusterin) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.41 / 1. The record also includes population frequency data and structural context.
E142K (p.Glu142Lys) variant details
- p.Glu142Lys
- cosmic curated COSV57065
- Missense
- Variant Prioritization Score for Impact Estimate 0.411
- REVEL 0.18
- CADD 23.50
- PolyPhen-2 0.12
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 2.7e-06)
- Structural context available