E142D (p.Glu142Asp) variant of CLU (Clusterin)
E142D (p.Glu142Asp) in CLU (Clusterin) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.26 / 1. The record also includes population frequency data and structural context.
E142D (p.Glu142Asp) variant details
- p.Glu142Asp
- gnomAD rs1370597528
- Missense
- Variant Prioritization Score for Impact Estimate 0.263
- REVEL 0.14
- CADD 17.20
- PolyPhen-2 0.32
- SIFT 0.20
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available