E112G (p.Glu112Gly) variant of CLU (Clusterin)
E112G (p.Glu112Gly) in CLU (Clusterin) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.65 / 1. The record also includes population frequency data and structural context.
E112G (p.Glu112Gly) variant details
- p.Glu112Gly
- TOPMed rs1461611022
- gnomAD rs1461611022
- Missense
- Variant Prioritization Score for Impact Estimate 0.646
- REVEL 0.61
- CADD 32.00
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the Latino/Admixed American population (allele frequency 6.5e-05)
- Structural context available