W22L (p.Trp22Leu) variant of CLCNKB (Chloride channel protein ClC-Kb)
W22L (p.Trp22Leu) in CLCNKB (Chloride channel protein ClC-Kb) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.70 / 1. The record also includes population frequency data and structural context.
W22L (p.Trp22Leu) variant details
- p.Trp22Leu
- gnomAD rs1279122450
- Missense
- Variant Prioritization Score for Impact Estimate 0.698
- REVEL 0.72
- CADD 24.50
- PolyPhen-2 1.00
- SIFT 0.03
- Population evidence available
- Structural context available