G84S (p.Gly84Ser) variant of CDX2 (Homeobox protein CDX-2)
G84S (p.Gly84Ser) in CDX2 (Homeobox protein CDX-2) is a missense change. Clinical records from ClinVar and UniProt describe it as uncertain significance in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.24 / 1. The record also includes population frequency data.
G84S (p.Gly84Ser) variant details
- p.Gly84Ser
- TOPMed rs903262296
- gnomAD rs903262296
- Uncertain significance
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.238
- REVEL 0.09
- MetaLR 0.06
- MetaSVM -1.02
- CADD 10.90
- PolyPhen-2 0.16
- SIFT 0.45
- ClinVar: Uncertain significance (not specified)
- UniProt: Uncertain significance
- Most common in the Latino/Admixed American population (allele frequency 5.6e-05)