L86M (p.Leu86Met) variant of CDKN2A (Tumor suppressor ARF)
L86M (p.Leu86Met) in CDKN2A (Tumor suppressor ARF) is a missense change. Clinical records from ClinVar and UniProt describe it as likely pathogenic in the context of Melanoma-pancreatic cancer syndrome; Hereditary cancer-predisposing syndrome. The record also includes structural context.
L86M (p.Leu86Met) variant details
- p.Leu86Met
- NCI-TCGA Cosmic COSV5868
- NCI-TCGA Cosmic COSV5869
- cosmic curated COSV58695
- Likely pathogenic
- Melanoma-pancreatic cancer syndrome; Hereditary cancer-predisposing syndrome
- Missense
- ClinVar: Likely pathogenic (Melanoma-pancreatic cancer syndrome; Hereditary cancer-predispos)
- UniProt: Likely pathogenic
- Structural context available