T35K (p.Thr35Lys) variant of CDKL5 (Cyclin-dependent kinase-like 5)
T35K (p.Thr35Lys) in CDKL5 (Cyclin-dependent kinase-like 5) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.57 / 1. The record also includes population frequency data, published literature, and structural context.
T35K (p.Thr35Lys) variant details
- p.Thr35Lys
- gnomAD X-18564481-C-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.572
- MetaLR 0.24
- MetaSVM -0.62
- CADD 24.40
- PolyPhen-2 0.48
- SIFT 0.00
- Population evidence available
- Structural context available
- Literature evidence available