G58W (p.Gly58Trp) variant of CDK9 (Cyclin-dependent kinase 9)
G58W (p.Gly58Trp) in CDK9 (Cyclin-dependent kinase 9) is a missense change. Clinical records from EBI and UniProt describe it as uncertain significance. The available variant effect predictions contribute to a CATVariant prioritization score of 0.77 / 1. The record also includes population frequency data and structural context.
G58W (p.Gly58Trp) variant details
- p.Gly58Trp
- ESP rs149950953
- ExAC rs149950953
- gnomAD rs149950953
- Uncertain significance
- Missense
- Variant Prioritization Score for Impact Estimate 0.775
- REVEL 0.73
- CADD 33.00
- PolyPhen-2 1.00
- SIFT 0.00
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Most common in the Non-Finnish European population (allele frequency 1.5e-05)
- Structural context available