F59L (p.Phe59Leu) variant of CDK9 (Cyclin-dependent kinase 9)
F59L (p.Phe59Leu) in CDK9 (Cyclin-dependent kinase 9) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.32 / 1. The record also includes population frequency data, published literature, and structural context.
F59L (p.Phe59Leu) variant details
- p.Phe59Leu
- rs55640715
- UniProt VAR 041982
- ESP rs55640715
- ExAC rs55640715
- Missense
- Variant Prioritization Score for Impact Estimate 0.323
- REVEL 0.21
- CADD 23.70
- PolyPhen-2 0.24
- SIFT 0.04
- Most common in the African/African-American population (allele frequency 9.7e-05)
- Structural context available
- Cited in: Patterns of somatic mutation in human cancer genomes. (PMID 17344846)