Y24C (p.Tyr24Cys) variant of CDK6 (Cyclin-dependent kinase 6)
Y24C (p.Tyr24Cys) in CDK6 (Cyclin-dependent kinase 6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.58 / 1. The record also includes population frequency data and structural context.
Y24C (p.Tyr24Cys) variant details
- p.Tyr24Cys
- TOPMed rs1003962156
- gnomAD rs1003962156
- Missense
- Variant Prioritization Score for Impact Estimate 0.582
- REVEL 0.59
- MetaLR 0.32
- MetaSVM -0.38
- CADD 31.00
- PolyPhen-2 1.00
- SIFT 0.01
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available