V45M (p.Val45Met) variant of CDK6 (Cyclin-dependent kinase 6)
V45M (p.Val45Met) in CDK6 (Cyclin-dependent kinase 6) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.54 / 1. The record also includes population frequency data and structural context.
V45M (p.Val45Met) variant details
- p.Val45Met
- NCI-TCGA TCGA novel
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.544
- REVEL 0.45
- MetaLR 0.29
- MetaSVM -0.46
- CADD 25.40
- PolyPhen-2 0.98
- SIFT 0.04
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the REMAINING population (allele frequency 1.7e-05)
- Structural context available