V45L (p.Val45Leu) variant of CDK6 (Cyclin-dependent kinase 6)
V45L (p.Val45Leu) in CDK6 (Cyclin-dependent kinase 6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.43 / 1. The record also includes population frequency data and structural context.
V45L (p.Val45Leu) variant details
- p.Val45Leu
- ExAC rs774217237
- TOPMed rs774217237
- gnomAD rs774217237
- Missense
- Variant Prioritization Score for Impact Estimate 0.431
- REVEL 0.28
- MetaLR 0.11
- MetaSVM -0.90
- CADD 23.10
- PolyPhen-2 0.15
- SIFT 0.10
- Most common in the Non-Finnish European population (allele frequency 7.2e-06)
- Structural context available