V16M (p.Val16Met) variant of CDK6 (Cyclin-dependent kinase 6)
V16M (p.Val16Met) in CDK6 (Cyclin-dependent kinase 6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.44 / 1. The record also includes population frequency data and structural context.
V16M (p.Val16Met) variant details
- p.Val16Met
- TOPMed rs1445849101
- gnomAD rs1445849101
- Missense
- Variant Prioritization Score for Impact Estimate 0.44
- REVEL 0.25
- MetaLR 0.23
- MetaSVM -0.70
- CADD 25.60
- PolyPhen-2 0.99
- SIFT 0.06
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available