R8S (p.Arg8Ser) variant of CDK6 (Cyclin-dependent kinase 6)
R8S (p.Arg8Ser) in CDK6 (Cyclin-dependent kinase 6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.46 / 1. The record also includes population frequency data and structural context.
R8S (p.Arg8Ser) variant details
- p.Arg8Ser
- TOPMed rs1801541400
- gnomAD rs1801541400
- Missense
- Variant Prioritization Score for Impact Estimate 0.456
- REVEL 0.34
- MetaLR 0.11
- MetaSVM -1.02
- CADD 22.70
- PolyPhen-2 0.02
- SIFT 0.84
- Most common in the East Asian population (allele frequency 0.00019)
- Structural context available