R8H (p.Arg8His) variant of CDK6 (Cyclin-dependent kinase 6)
R8H (p.Arg8His) in CDK6 (Cyclin-dependent kinase 6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.36 / 1. The record also includes population frequency data and structural context.
R8H (p.Arg8His) variant details
- p.Arg8His
- TOPMed rs1801541322
- gnomAD rs1801541322
- Missense
- Variant Prioritization Score for Impact Estimate 0.361
- REVEL 0.14
- MetaLR 0.16
- MetaSVM -1.03
- CADD 23.10
- PolyPhen-2 0.00
- SIFT 0.19
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available