R8C (p.Arg8Cys) variant of CDK6 (Cyclin-dependent kinase 6)
R8C (p.Arg8Cys) in CDK6 (Cyclin-dependent kinase 6) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.48 / 1. The record also includes population frequency data and structural context.
R8C (p.Arg8Cys) variant details
- p.Arg8Cys
- NCI-TCGA Cosmic COSV5601
- cosmic curated COSV56011
- TOPMed rs1801541400
- gnomAD rs1801541400
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.484
- REVEL 0.38
- MetaLR 0.17
- MetaSVM -0.55
- CADD 24.60
- PolyPhen-2 0.15
- SIFT 0.06
- UniProt: Variant assessed as somatic; moderate impact.
- Population evidence available
- Structural context available