R46W (p.Arg46Trp) variant of CDK6 (Cyclin-dependent kinase 6)
R46W (p.Arg46Trp) in CDK6 (Cyclin-dependent kinase 6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.53 / 1. The record also includes population frequency data and structural context.
R46W (p.Arg46Trp) variant details
- p.Arg46Trp
- cosmic curated COSV56011
- gnomAD rs1290397698
- Missense
- Variant Prioritization Score for Impact Estimate 0.531
- REVEL 0.48
- MetaLR 0.43
- MetaSVM -0.12
- CADD 32.00
- PolyPhen-2 0.99
- SIFT 0.00
- Most common in the Latino/Admixed American population (allele frequency 2.3e-05)
- Structural context available