L6V (p.Leu6Val) variant of CDK6 (Cyclin-dependent kinase 6)
L6V (p.Leu6Val) in CDK6 (Cyclin-dependent kinase 6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.25 / 1. The record also includes population frequency data and structural context.
L6V (p.Leu6Val) variant details
- p.Leu6Val
- 1000Genomes rs556194182
- ExAC rs556194182
- TOPMed rs556194182
- gnomAD rs556194182
- Missense
- Variant Prioritization Score for Impact Estimate 0.247
- REVEL 0.06
- MetaLR 0.18
- MetaSVM -0.97
- CADD 22.10
- PolyPhen-2 0.00
- SIFT 0.32
- Most common in the Non-Finnish European population (allele frequency 8.1e-06)
- Structural context available