L6R (p.Leu6Arg) variant of CDK6 (Cyclin-dependent kinase 6)
L6R (p.Leu6Arg) in CDK6 (Cyclin-dependent kinase 6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.37 / 1. The record also includes population frequency data and structural context.
L6R (p.Leu6Arg) variant details
- p.Leu6Arg
- cosmic curated COSV10722
- Missense
- Variant Prioritization Score for Impact Estimate 0.375
- REVEL 0.25
- MetaLR 0.17
- MetaSVM -0.96
- CADD 24.50
- PolyPhen-2 0.02
- SIFT 0.13
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available