L6P (p.Leu6Pro) variant of CDK6 (Cyclin-dependent kinase 6)
L6P (p.Leu6Pro) in CDK6 (Cyclin-dependent kinase 6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.31 / 1. The record also includes population frequency data and structural context.
L6P (p.Leu6Pro) variant details
- p.Leu6Pro
- Ensembl rs2116034852
- Missense
- Variant Prioritization Score for Impact Estimate 0.314
- REVEL 0.13
- MetaLR 0.17
- MetaSVM -0.89
- CADD 24.70
- PolyPhen-2 0.00
- SIFT 0.07
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available