K34R (p.Lys34Arg) variant of CDK6 (Cyclin-dependent kinase 6)
K34R (p.Lys34Arg) in CDK6 (Cyclin-dependent kinase 6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.37 / 1. The record also includes population frequency data and structural context.
K34R (p.Lys34Arg) variant details
- p.Lys34Arg
- Ensembl rs2116033279
- Missense
- Variant Prioritization Score for Impact Estimate 0.366
- REVEL 0.23
- MetaLR 0.17
- MetaSVM -0.92
- CADD 23.50
- PolyPhen-2 0.00
- SIFT 0.45
- Most common in the Middle Eastern population (allele frequency 0.00017)
- Structural context available