G5C (p.Gly5Cys) variant of CDK6 (Cyclin-dependent kinase 6)
G5C (p.Gly5Cys) in CDK6 (Cyclin-dependent kinase 6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.26 / 1. The record also includes population frequency data and structural context.
G5C (p.Gly5Cys) variant details
- p.Gly5Cys
- 1000Genomes rs576150359
- ExAC rs576150359
- gnomAD rs576150359
- Missense
- Variant Prioritization Score for Impact Estimate 0.261
- REVEL 0.22
- MetaLR 0.21
- MetaSVM -0.77
- CADD 21.70
- PolyPhen-2 0.37
- SIFT 0.05
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available