G22S (p.Gly22Ser) variant of CDK6 (Cyclin-dependent kinase 6)
G22S (p.Gly22Ser) in CDK6 (Cyclin-dependent kinase 6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.91 / 1. The record also includes population frequency data and structural context.
G22S (p.Gly22Ser) variant details
- p.Gly22Ser
- Ensembl rs2116033933
- Missense
- Variant Prioritization Score for Impact Estimate 0.905
- REVEL 0.96
- MetaLR 0.96
- MetaSVM 1.09
- CADD 28.00
- PolyPhen-2 1.00
- SIFT 0.02
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available