E21K (p.Glu21Lys) variant of CDK6 (Cyclin-dependent kinase 6)
E21K (p.Glu21Lys) in CDK6 (Cyclin-dependent kinase 6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.43 / 1. The record also includes population frequency data and structural context.
E21K (p.Glu21Lys) variant details
- p.Glu21Lys
- 1000Genomes rs1199476203
- TOPMed rs1199476203
- gnomAD rs1199476203
- Missense
- Variant Prioritization Score for Impact Estimate 0.429
- REVEL 0.27
- MetaLR 0.11
- MetaSVM -0.89
- CADD 22.80
- PolyPhen-2 0.12
- SIFT 0.84
- Most common in the Non-Finnish European population (allele frequency 1.5e-05)
- Structural context available