E18K (p.Glu18Lys) variant of CDK6 (Cyclin-dependent kinase 6)
E18K (p.Glu18Lys) in CDK6 (Cyclin-dependent kinase 6) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.52 / 1. The record also includes population frequency data and structural context.
E18K (p.Glu18Lys) variant details
- p.Glu18Lys
- NCI-TCGA Cosmic COSV5600
- NCI-TCGA Cosmic COSV5601
- cosmic curated COSV56010
- Ensembl rs2116034204
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.518
- REVEL 0.42
- MetaLR 0.19
- MetaSVM -0.84
- CADD 24.20
- PolyPhen-2 1.00
- SIFT 0.19
- UniProt: Variant assessed as somatic; moderate impact.
- Population evidence available
- Structural context available