E14K (p.Glu14Lys) variant of CDK6 (Cyclin-dependent kinase 6)
E14K (p.Glu14Lys) in CDK6 (Cyclin-dependent kinase 6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.52 / 1. The record also includes population frequency data and structural context.
E14K (p.Glu14Lys) variant details
- p.Glu14Lys
- ExAC rs766582975
- TOPMed rs766582975
- gnomAD rs766582975
- Missense
- Variant Prioritization Score for Impact Estimate 0.52
- REVEL 0.37
- MetaLR 0.26
- MetaSVM -0.52
- CADD 32.00
- PolyPhen-2 0.91
- SIFT 0.02
- Most common in the Non-Finnish European population (allele frequency 3.6e-06)
- Structural context available