C15R (p.Cys15Arg) variant of CDK6 (Cyclin-dependent kinase 6)
C15R (p.Cys15Arg) in CDK6 (Cyclin-dependent kinase 6) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.32 / 1. The record also includes population frequency data and structural context.
C15R (p.Cys15Arg) variant details
- p.Cys15Arg
- ExAC rs758530954
- gnomAD rs758530954
- Missense
- Variant Prioritization Score for Impact Estimate 0.317
- REVEL 0.15
- MetaLR 0.03
- MetaSVM -1.10
- CADD 23.40
- PolyPhen-2 0.12
- SIFT 0.54
- Most common in the Latino/Admixed American population (allele frequency 2.2e-05)
- Structural context available