T3S (p.Thr3Ser) variant of CDK4 (Cyclin-dependent kinase 4)
T3S (p.Thr3Ser) in CDK4 (Cyclin-dependent kinase 4) is a missense change. Clinical records from EBI and UniProt describe it as likely benign. The available variant effect predictions contribute to a CATVariant prioritization score of 0.18 / 1. The record also includes population frequency data and structural context.
T3S (p.Thr3Ser) variant details
- p.Thr3Ser
- Ensembl rs2140388808
- Likely benign
- Missense
- Variant Prioritization Score for Impact Estimate 0.178
- REVEL 0.04
- AlphaMissense 0.09
- MetaLR 0.07
- MetaSVM -1.02
- CADD 16.20
- PolyPhen-2 0.00
- EBI: Likely benign
- UniProt: Likely benign
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available