P8L (p.Pro8Leu) variant of CDK4 (Cyclin-dependent kinase 4)
P8L (p.Pro8Leu) in CDK4 (Cyclin-dependent kinase 4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.43 / 1. The record also includes population frequency data and structural context.
P8L (p.Pro8Leu) variant details
- p.Pro8Leu
- Ensembl rs2140388756
- Missense
- Variant Prioritization Score for Impact Estimate 0.427
- REVEL 0.21
- CADD 23.40
- PolyPhen-2 0.03
- SIFT 0.30
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available