L108Q (p.Leu108Gln) variant of CDK2 (Cyclin-dependent kinase 2)
L108Q (p.Leu108Gln) in CDK2 (Cyclin-dependent kinase 2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.66 / 1. The record also includes population frequency data, published literature, and structural context.
L108Q (p.Leu108Gln) variant details
- p.Leu108Gln
- gnomAD 12-55968785-T-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.66
- REVEL 0.80
- AlphaMissense 0.40
- MetaLR 0.12
- MetaSVM -0.97
- CADD 28.10
- PolyPhen-2 1.00
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available
- Literature evidence available