K105M (p.Lys105Met) variant of CDK2 (Cyclin-dependent kinase 2)
K105M (p.Lys105Met) in CDK2 (Cyclin-dependent kinase 2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.71 / 1. The record also includes population frequency data and structural context.
K105M (p.Lys105Met) variant details
- p.Lys105Met
- gnomAD rs1439814067
- Missense
- Variant Prioritization Score for Impact Estimate 0.707
- REVEL 0.71
- CADD 33.00
- PolyPhen-2 0.99
- SIFT 0.00
- Most common in the Ashkenazi Jewish population (allele frequency 0.00029)
- Structural context available