G13D (p.Gly13Asp) variant of CDK2 (Cyclin-dependent kinase 2)
G13D (p.Gly13Asp) in CDK2 (Cyclin-dependent kinase 2) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.90 / 1. The record also includes population frequency data and structural context.
G13D (p.Gly13Asp) variant details
- p.Gly13Asp
- rs1399364791
- NCI-TCGA Cosmic COSV5718
- cosmic curated COSV57186
- TOPMed rs1399364791
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.9
- REVEL 0.95
- CADD 32.00
- PolyPhen-2 1.00
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the African/African-American population (allele frequency 3e-05)
- Structural context available