F4L (p.Phe4Leu) variant of CDK2 (Cyclin-dependent kinase 2)
F4L (p.Phe4Leu) in CDK2 (Cyclin-dependent kinase 2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.41 / 1. The record also includes population frequency data, published literature, and structural context.
F4L (p.Phe4Leu) variant details
- p.Phe4Leu
- gnomAD 12-55967020-C-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.413
- REVEL 0.33
- CADD 24.60
- PolyPhen-2 0.21
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available