F109L (p.Phe109Leu) variant of CDK2 (Cyclin-dependent kinase 2)
F109L (p.Phe109Leu) in CDK2 (Cyclin-dependent kinase 2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.30 / 1. The record also includes population frequency data and structural context.
F109L (p.Phe109Leu) variant details
- p.Phe109Leu
- cosmic curated COSV57186
- ExAC rs756703184
- TOPMed rs756703184
- gnomAD rs756703184
- Missense
- Variant Prioritization Score for Impact Estimate 0.297
- REVEL 0.26
- CADD 21.40
- PolyPhen-2 0.00
- SIFT 0.11
- Most common in the East Asian population (allele frequency 0.00039)
- Structural context available