S25P (p.Ser25Pro) variant of CDK12 (Cyclin-dependent kinase 12)
S25P (p.Ser25Pro) in CDK12 (Cyclin-dependent kinase 12) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.28 / 1. The record also includes population frequency data and structural context.
S25P (p.Ser25Pro) variant details
- p.Ser25Pro
- NCI-TCGA TCGA novel
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.278
- REVEL 0.22
- CADD 24.70
- PolyPhen-2 0.96
- SIFT 0.06
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 2.7e-06)
- Structural context available